ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect

Irina Martynenko; Vera Kuznetsova; Anna Orlova; Pavel Kanaev; Yulia Gromova; Vladimir Maslov; Alex Baranov; Anatoly Fedorov

doi:10.1117/12.2052528

2 May 2014 ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect

Irina Martynenko, Vera Kuznetsova, Anna Orlova, Pavel Kanaev, Yulia Gromova, Vladimir Maslov, Alex Baranov, Anatoly Fedorov

Author Affiliations +

Proceedings Volume 9126, Nanophotonics V; 91263C (2014) https://doi.org/10.1117/12.2052528
Event: SPIE Photonics Europe, 2014, Brussels, Belgium

Abstract

In present study complexes between non-toxic ZnSe/ZnS quantum dots and chlorin e6 molecules that are widely used as photosensitizers in photodynamic therapy were formed. It was found that in aqueous solution cationic ZnSe/ZnS quantum dots and chlorin e6 formed stable complexes that exhibit efficient photoexcitation energy transfer from quantum dots to molecules. Spectroscopic methods were applied to evaluate the energy transfer efficiency. Stoichiometry of these complexes was studied. Additionally, the photodynamic therapy efficacy of the quantum dotchlorin e6 complexes was in vitro assessed against Ehrlich ascites carcinoma cancer cell line using a trypan blue assay. We found that complex offered an improved cancer cell photodynamic destruction effect as compared to that of free chlorin e6.

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Irina Martynenko, Vera Kuznetsova, Anna Orlova, Pavel Kanaev, Yulia Gromova, Vladimir Maslov, Alex Baranov, and Anatoly Fedorov "ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect", Proc. SPIE 9126, Nanophotonics V, 91263C (2 May 2014); https://doi.org/10.1117/12.2052528

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