Probe-pin device for optical neurotransmitter sensing in the brain

Min Hyuck Kim; Kyo D. Song; Hargsoon Yoon; Yeonjoon Park; Sang H. Choi; Dae-Sung Lee; Kyu-Sik Shin; Hak-In Hwang; Uhn Lee

doi:10.1117/12.2085610

3 April 2015 Probe-pin device for optical neurotransmitter sensing in the brain

Min Hyuck Kim, Kyo D. Song, Hargsoon Yoon, Yeonjoon Park, Sang H. Choi, Dae-Sung Lee, Kyu-Sik Shin, Hak-In Hwang, Uhn Lee

Author Affiliations +

Proceedings Volume 9434, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2015; 943409 (2015) https://doi.org/10.1117/12.2085610
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2015, San Diego, California, United States

Abstract

Development of an optical neurotransmitter sensing device using nano-plasmonic probes and a micro-spectrometer for real time monitoring of neural signals in the brain is underway. Clinical application of this device technology is to provide autonomous closed-loop feedback control to a deep brain stimulation (DBS) system and enhance the accuracy and efficacy of DBS treatment. By far, we have developed an implantable probe-pin device based on localized field enhancement of surface plasmonic resonance on a nanostructured sensing domain which can amplify neurochemical signals from evoked neural activity in the brain. In this paper, we will introduce the details of design and sensing performance of a proto-typed microspectrometer and nanostructured probing devices for real time measurement of neurotransmitter concentrations.

Citation Download Citation

Min Hyuck Kim, Kyo D. Song, Hargsoon Yoon, Yeonjoon Park, Sang H. Choi, Dae-Sung Lee, Kyu-Sik Shin, Hak-In Hwang, and Uhn Lee "Probe-pin device for optical neurotransmitter sensing in the brain", Proc. SPIE 9434, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2015, 943409 (3 April 2015); https://doi.org/10.1117/12.2085610

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE