Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique

Ajeetkumar Patil; Unnikrishnan V. K.; Ravikiran Ongole; Keerthilatha M. Pai; V. B. Kartha; Santhosh Chidangil

doi:10.1117/12.2184964

15 July 2015 Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique

Ajeetkumar Patil, Unnikrishnan V. K., Ravikiran Ongole, Keerthilatha M. Pai, V. B. Kartha, Santhosh Chidangil

Proceedings Volume 9537, Clinical and Biomedical Spectroscopy and Imaging IV; 95370J (2015) https://doi.org/10.1117/12.2184964
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

Oral cancer together with pharyngeal cancer is the sixth most common malignancy reported worldwide and one with high mortality ratio among all malignancies [1]. Worldwide 450,000 new cases are estimated in 2014[2]. About 90% are a type of cancer called squamous cell carcinoma (SCC). SCC of the tongue is the most common oral malignancy accounting for approximately 40% of all oral carcinomas. One of the important factors for successful therapy of any malignancy is early diagnosis. Although considerable progress has been made in understanding the cellular and molecular mechanisms of tumorigenesis, lack of reliable diagnostic methods for early detection leading to delay in therapy is an important factor responsible for the increase in the mortality rate in various types of cancers. Spectroscopy techniques are extremely sensitive for the analysis of biochemical changes in cellular systems. These techniques can provide a valuable information on alterations that occur during the development of cancer. This is especially important in oral cancer, where "tumor detection is complicated by a tendency towards field cancerization, leading to multi-centric lesions" and "current techniques detect malignant change too late" [3], and "biopsies are not representative of the whole premalignant lesion". [4]

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Ajeetkumar Patil, Unnikrishnan V. K., Ravikiran Ongole, Keerthilatha M. Pai, V. B. Kartha, and Santhosh Chidangil "Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95370J (15 July 2015); https://doi.org/10.1117/12.2184964

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KEYWORDS

Tongue

Cancer

Laser induced fluorescence

Principal component analysis

Luminescence

Spectroscopy

Fluorescence spectroscopy

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