Microfluidic in-channel multi-electrode platform for neurotransmitter sensing

A. Kara; J. Mathault; A. Reitz; M. Boisvert; F. Tessier; J. Greener; A. Miled

doi:10.1117/12.2211763

21 March 2016 Microfluidic in-channel multi-electrode platform for neurotransmitter sensing

A. Kara, J. Mathault, A. Reitz, M. Boisvert, F. Tessier, J. Greener, A. Miled

Proceedings Volume 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV; 97050X (2016) https://doi.org/10.1117/12.2211763
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

In this project we present a microfluidic platform with in-channel micro-electrodes for in situ screening of bio/chemical samples through a lab-on-chip system. We used a novel method to incorporate electrochemical sensors array (16x20) connected to a PCB, which opens the way for imaging applications. A 200 μm height microfluidic channel was bonded to electrochemical sensors. The micro-channel contains 3 inlets used to introduce phosphate buffer saline (PBS), ferrocynide and neurotransmitters. The flow rate was controlled through automated micro-pumps. A multiplexer was used to scan electrodes and perform individual cyclic voltammograms by a custom potentiostat. The behavior of the system was linear in terms of variation of current versus concentration. It was used to detect the neurotransmitters serotonin, dopamine and glutamate.

Citation Download Citation

A. Kara, J. Mathault, A. Reitz, M. Boisvert, F. Tessier, J. Greener, and A. Miled "Microfluidic in-channel multi-electrode platform for neurotransmitter sensing", Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 97050X (21 March 2016); https://doi.org/10.1117/12.2211763

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