Effectiveness of surface enhanced Raman spectroscopy of tear fluid with soft substrate for point-of-care therapeutic drug monitoring

K. Yamada; T. Endo; H. Imai; M. Kido; H. Jeong; Y. Ohno

doi:10.1117/12.2214614

4 March 2016 Effectiveness of surface enhanced Raman spectroscopy of tear fluid with soft substrate for point-of-care therapeutic drug monitoring

K. Yamada, T. Endo, H. Imai, M. Kido, H. Jeong, Y. Ohno

Author Affiliations +

Proceedings Volume 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics; 97150E (2016) https://doi.org/10.1117/12.2214614
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We have developed the point-of-care therapeutic drug monitoring kit based on Raman Spectroscopy of tear fluid. In this study, we were examined a soft substrate for an optimal lattice based on nanoimprint lithography using cyclo-olefin polymer to improve the sensitivity for measuring drug concentration in tear fluid. This is photonics crystal which is one of the nano-photonics based device was fabricated. Target is Sodium Phenobarbital which is an anticonvulsant agent. We show the effectiveness of Surface Enhanced Raman Spectroscopy of tear fluid with soft substrate for point-of-care therapeutic drug monitoring.

Conference Presentation

Citation Download Citation

K. Yamada, T. Endo, H. Imai, M. Kido, H. Jeong, and Y. Ohno "Effectiveness of surface enhanced Raman spectroscopy of tear fluid with soft substrate for point-of-care therapeutic drug monitoring", Proc. SPIE 9715, Optical Diagnostics and Sensing XVI: Toward Point-of-Care Diagnostics, 97150E (4 March 2016); https://doi.org/10.1117/12.2214614

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