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We demonstrate a single multi-mode fiber-based micro-endoscope for measuring blood flow speeds. We use the transmission-matrix wavefront shaping approach to calibrate the multi-mode fiber and raster-scan a focal spot across the distal fiber facet, imaging the cross-polarized back-reflected light at the proximal facet using a camera. This setup allows assessment of the backscattered photon statistics: by computing the mean speckle contrast values across the proximal fiber facet we show that spatially-resolved flow speed maps can be inferred by selecting an appropriate camera integration time. The proposed system is promising for minimally-invasive studies of neurovascular coupling in deep brain structures.
Iliya Sigal,Antonio M. Caravaca Aguirre,Raanan Gad,Rafael Piestun, andOfer Levi
"Label free imaging system for measuring blood flow speeds using a single multi-mode optical fiber (Conference Presentation)", Proc. SPIE 9717, Adaptive Optics and Wavefront Control for Biological Systems II, 97171G (26 May 2016); https://doi.org/10.1117/12.2213173
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Iliya Sigal, Antonio M. Caravaca Aguirre, Raanan Gad, Rafael Piestun, Ofer Levi, "Label free imaging system for measuring blood flow speeds using a single multi-mode optical fiber (Conference Presentation)," Proc. SPIE 9717, Adaptive Optics and Wavefront Control for Biological Systems II, 97171G (26 May 2016); https://doi.org/10.1117/12.2213173