A new method is described which enhances classical photodynamic action (PA) by adding electricity. Rather than producing singlet oxygen, the electrical enhancement of photodynamic action (EE-PA) drives the photochemical reactions towards the creation of superoxide, and other, oxygen radicals. The benefits of EE-PA over PA are illustrated by reviewing results from four groups of experiments where this process was used either to inactivate Herpes viruses, gliosarcomas, bacteria, or to enable charge transfer to oxidized hemoglobin. The experiments have suggested several advantages of EE-PA over traditional photodynamic action (PA).
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