Cutaneous pharmacokinetics of escalating Ruxolitinib formulation doses utilizing a coherent Raman imaging pipeline

Benjamin Kuzma; Thomas Würthwein; Nick Lemberger; Kristin Wallmeier; Carsten Fallnich; Conor L. Evans; Kim Troensegaard Nielsen; Louise Bastholm Jensen; Lars Svensson; Jean-Luc Tran

doi:10.1117/12.2608845

7 March 2022 Cutaneous pharmacokinetics of escalating Ruxolitinib formulation doses utilizing a coherent Raman imaging pipeline

Benjamin Kuzma, Thomas Würthwein, Nick Lemberger, Kristin Wallmeier, Carsten Fallnich, Conor L. Evans, Kim Troensegaard Nielsen, Louise Bastholm Jensen, Lars Svensson, Jean-Luc Tran

Author Affiliations +

Proceedings Volume PC11938, Visualizing and Quantifying Drug Distribution in Tissue VI; PC1193808 (2022) https://doi.org/10.1117/12.2608845
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Systemic drug delivery for dermatological conditions yields little drug to the intended site of action resulting in adverse effects. Topical drug delivery is a viable alternative yet the local cutaneous pharmacokinetics (cPK) is relatively under-explored. Product dosing is dependent upon the knowledge of the dose-cPK relationship, which coincides with the pharmacodynamic (PD) activity. Coherent Raman imaging (CRI) can quantify tissue-specific drug localization and elucidate micro-scale cPK estimates, affording a clinically relevant cPK-PD relationship. This demonstration of a dose-cPK relationship utilizing CRI offers a stepping stone for additional formulation evaluation ex vivo.

Conference Presentation

Citation Download Citation

Benjamin Kuzma, Thomas Würthwein, Nick Lemberger, Kristin Wallmeier, Carsten Fallnich, Conor L. Evans, Kim Troensegaard Nielsen, Louise Bastholm Jensen, Lars Svensson, and Jean-Luc Tran "Cutaneous pharmacokinetics of escalating Ruxolitinib formulation doses utilizing a coherent Raman imaging pipeline", Proc. SPIE PC11938, Visualizing and Quantifying Drug Distribution in Tissue VI, PC1193808 (7 March 2022); https://doi.org/10.1117/12.2608845

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Coherence imaging

Raman spectroscopy

Ear

Tissues

Skin

Keywords/Phrases

Search In:

Publication Years