CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC11944 > Article
Presentation
7 March 2022 Optical scattering serves as a prognostic biomarker for immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model
Anup Tank, Cameron Vergato, David J. Waxman, Darren M. Roblyer
Author Affiliations +
Proceedings Volume PC11944, Multiscale Imaging and Spectroscopy III; PC1194407 (2022) https://doi.org/10.1117/12.2608388
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Spatial Frequency Domain Imaging (SFDI) can provide longitudinal label-free, wide field hemodynamic and scattering information of murine tumors. Here we present a longitudinal study utilizing SFDI to monitor a paired immune responsive-resistant model for up to 30 days of treatment. Mice receiving the immunomodulatory treatment had a large increase in the reduced optical scattering throughout treatment compared to the mice receiving an immune-blocking antibody. These results indicate that scattering is sensitive to the immune-mediated apoptosis of tumor cells and capable of discriminating between responsive and resistant tumor models.
Conference Presentation
© (2022) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Anup Tank, Cameron Vergato, David J. Waxman, and Darren M. Roblyer "Optical scattering serves as a prognostic biomarker for immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model", Proc. SPIE PC11944, Multiscale Imaging and Spectroscopy III, PC1194407 (7 March 2022); https://doi.org/10.1117/12.2608388
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
;
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Scattering
Tumors
Breast cancer
Resistance
Tumor growth modeling
Cell death
In vivo imaging
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top