Determining the effect of radiotherapy on the optical properties of white matter of the brain using cross-polarization OCT

Ksenia A. Achkasova; Konstantin S. Yashin; Alexander A. Moiseev; Elena B. Kiseleva; Evgenia L. Bederina; Igor A. Medyanik; Natalia D. Gladkova

doi:10.1117/12.2607025

7 March 2022 Determining the effect of radiotherapy on the optical properties of white matter of the brain using cross-polarization OCT

Ksenia A. Achkasova, Konstantin S. Yashin, Alexander A. Moiseev, Elena B. Kiseleva, Evgenia L. Bederina, Igor A. Medyanik, Natalia D. Gladkova

Author Affiliations +

Proceedings Volume PC11945, Clinical and Translational Neurophotonics 2022; PC1194507 (2022) https://doi.org/10.1117/12.2607025
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The current study is aimed at investigating the influence of radiotherapy on the optical properties of white matter in patients with brain gliomas using cross-polarization OCT. It was performed on ex vivo samples of peritumoral white matter collected from patients with primary surgery and patients who underwent a course of radiotherapy before surgery. The enhancement of scattering properties in case of use of radiotherapy was detected and the optical coefficients that most accurately reflect the relationship between the optical and morphological properties of white matter in both groups of patients were determined.

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Ksenia A. Achkasova, Konstantin S. Yashin, Alexander A. Moiseev, Elena B. Kiseleva, Evgenia L. Bederina, Igor A. Medyanik, and Natalia D. Gladkova "Determining the effect of radiotherapy on the optical properties of white matter of the brain using cross-polarization OCT", Proc. SPIE PC11945, Clinical and Translational Neurophotonics 2022, PC1194507 (7 March 2022); https://doi.org/10.1117/12.2607025

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