Ophthalmic OCT image-quality is highly variable and directly impacts clinical diagnosis of disease. Computational methods such as frame-averaging, filtering, deep-learning approaches are generally constrained by either extended imaging times when acquiring repeated-frames, over-smoothing and loss of features, or the need for extensive training sets. Self-fusion is a robust OCT image-enhancement method that overcomes these aforementioned limitations by averaging serial OCT frames weighted by their respective similarity. Here, we demonstrated video-rate self-fusion using a convolutional neural network. Our experimental results show a near doubling of OCT contrast-to-noise ratio at a frame-rate of ~22 fps when integrated with custom OCT acquisition software.
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