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2 March 2022 Phenotyping human tumor immune microenvironment (TiME) in vivo in patients to predict response to immunotherapy
Aditi Sahu, Teguru Tembo, Kivanc Kose, Anthony Santella, Anabel Alfonso, Miguel Cordova, Madison Li, Melissa Gill, Christi Alessi-Fox, Salvador Gonzalez, Amber Weiching Wang, Nicholas R. Kurtansky, Pratik Chandrani, Piyush Kumar, Shen Yin, Haaris Jilani, Paras Mehta, Gary Peterson, Cristian Navarrete-Dechent, Kimeil King, Stephen Dusza, Ning Yang, Shuaitong Li, William Phillips, Anthony Rossi, Allan Halpern, Liang Deng M.D., Melissa Pulitzer, Chih-Shan Jason Chen, Ashfaq Marghoob, Milind Rajadhyaksha
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Proceedings Volume PC11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022; PC1197207 (2022) https://doi.org/10.1117/12.2610517
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
There is an urgent need for predictive platforms for response to immunotherapy in patients. In vivo phenotyping of tumor-immune microenvironment (TiME) for predicting response to immunotherapy was evaluated using non-invasive reflectance confocal microscopy (RCM) in skin cancer patients. Phenotypes were correlated with underlying biology and response to topical immunotherapy. Using both inflammation and vasculature features, four major phenotypes were observed. The VaschiInfhi phenotype correlated with high immune activation, exhaustion, and vascular signatures while VaschiInflo with endothelial anergy and immune exclusion. Highest response to immunotherapy was seen in VascloInfhi phenotype. This study establishes proof-of-concept for in vivo TiME phenotyping in patients.
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Aditi Sahu, Teguru Tembo, Kivanc Kose, Anthony Santella, Anabel Alfonso, Miguel Cordova, Madison Li, Melissa Gill, Christi Alessi-Fox, Salvador Gonzalez, Amber Weiching Wang, Nicholas R. Kurtansky, Pratik Chandrani, Piyush Kumar, Shen Yin, Haaris Jilani, Paras Mehta, Gary Peterson, Cristian Navarrete-Dechent, Kimeil King, Stephen Dusza, Ning Yang, Shuaitong Li, William Phillips, Anthony Rossi, Allan Halpern, Liang Deng M.D., Melissa Pulitzer, Chih-Shan Jason Chen, Ashfaq Marghoob, and Milind Rajadhyaksha "Phenotyping human tumor immune microenvironment (TiME) in vivo in patients to predict response to immunotherapy", Proc. SPIE PC11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022, PC1197207 (2 March 2022); https://doi.org/10.1117/12.2610517
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KEYWORDS
Tumors
In vivo imaging
Inflammation
Lymphatic system
Modulation
Oncology
Profiling
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