Coherent Raman Scattering with STELLARIS 8 CRS – Applications and Innovations

Volker Schweikhard

doi:10.1117/12.2610641

2 March 2022 Coherent Raman Scattering with STELLARIS 8 CRS – Applications and Innovations

Volker Schweikhard

Proceedings Volume PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022; PC119730N (2022) https://doi.org/10.1117/12.2610641
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Coherent Raman Scattering microscopy (CRS) is a powerful approach for label-free, chemically specific imaging, based on the characteristic vibrational contrast of the sample molecules. Here, we introduce the all-new Leica STELLARIS 8 CRS microscope, a multi-modal optical discovery instrument that offers a unique combination of biochemical, biophysical and molecular contrasts. This is achieved by a seamless integration of Stimulated Raman Scattering (SRS), CARS, two-photon fluorescence and second-harmonic generation, with the STELLARIS confocal microscope. We will present applications in neurodegenerative disease, cancer, 3D biology, stem cell and developmental biology, and pharmacology.

Conference Presentation

Citation Download Citation

Volker Schweikhard "Coherent Raman Scattering with STELLARIS 8 CRS – Applications and Innovations", Proc. SPIE PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022, PC119730N (2 March 2022); https://doi.org/10.1117/12.2610641

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