PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Flow cytometry is the most common technique used to probe heterogeneous populations of cells in a high throughput manner. We are interested in the limit when (1) the occurrence of a specific target biomarker is rare and (2) biomarker concentration is low. Here we discuss a framework for in-situ characterizing signal noise levels in those systems, and the use of quantum measurement to optimize detection. Our method enables us to measure biomarker concentration and unambiguously identify the presence of a single emitter from first principles: i.e. without the need for auxiliary calibration.
Javier Sabines-Chesterking,Ivan A. Burenkov, andSergey V. Polyakov
"A framework for quantum-enhanced rare event detection in flow cytometry", Proc. SPIE PC12016, Optical and Quantum Sensing and Precision Metrology II, PC120161E (9 March 2022); https://doi.org/10.1117/12.2609768
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Javier Sabines-Chesterking, Ivan A. Burenkov, Sergey V. Polyakov, "A framework for quantum-enhanced rare event detection in flow cytometry," Proc. SPIE PC12016, Optical and Quantum Sensing and Precision Metrology II, PC120161E (9 March 2022); https://doi.org/10.1117/12.2609768