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Plasmon-enhanced biosensing has attracted considerable attention due to its capability of highly sensitive biomolecular detection and analysis. Here, we demonstrate several types of gap-mode plasmon-enhanced spectroscopies for detection of biomolecular complexes. The first one is demonstrated with a nanometric gap between a silver tip and gold substrate, enabling to detect gap-enhanced Raman scattering from an inorganic-binding peptide and to spectroscopically elucidate the binding dynamics and mechanism. The other demonstration is based on gap-mode SPR sensing of coronavirus (SARS-CoV-2) in which antibody-functionalized gold nanoparticle with relatively large diameter played crucial plasmonic roles in detecting SARS-CoV-2 nucleocapsid proteins at femtomolar lever.
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