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Recent technological innovations are finding their way into biomedical imaging systems just in time to impact emerging therapeutic innovations for some of the most challenging human health problems, such as cancer and neurodegenerative diseases. Imaging with high-energy photons and alpha/beta particles is especially useful in supporting research and personalized medicine in the rapidly developing field of targeted radiotherapy, where it is important to understand the details of dose delivery. In this context, we will consider the significance of novel geometries for direct- and indirect-conversion detectors and cameras, new architectures for data acquisition systems, new fabrication methods, and new computing platforms for physics modeling and image reconstruction.
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