Study of the action of curcuminoids in the photodynamic inactivation of bacteria resistant to antibiotics

Taina Cappellini; Jennifer M. Soares; Kate C. Blanco; Natalia M. Inada; Vanderlei Bagnato

doi:10.1117/12.3004522

13 March 2024 Study of the action of curcuminoids in the photodynamic inactivation of bacteria resistant to antibiotics

Taina Cappellini, Jennifer M. Soares, Kate C. Blanco, Natalia M. Inada, Vanderlei Bagnato

Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220X (2024) https://doi.org/10.1117/12.3004522
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

The rise of antibiotic-resistant infectious diseases is becoming an alarming problem for public health to the difficulty of treatment, resulting in a high number of deaths annually. Photodynamic inactivation (PDI) has shown promise as an effective method, which is based on the use of a photosensitize, when activated by light, generates reactive oxygen species (ROS), causing damage to the metabolic and structures of target cells, resulting in their death. This study aims to analyze the action of curcumin acting as a photosensitizer and the effect on the susceptibility of different antibiotics to Staphylococcus aureus resistant to methicillin (MRSA). The experimental groups and the analyzes were established from the central composite planning (10 µM, 10 J/cm²). The results demonstrated that PDI reduces the concentration of antibiotics needed to act against MRSA compared to the results of the control group. Combining both treatments enhances the action against target cells, enabling successful results.

Citation Download Citation

Taina Cappellini, Jennifer M. Soares, Kate C. Blanco, Natalia M. Inada, and Vanderlei Bagnato "Study of the action of curcuminoids in the photodynamic inactivation of bacteria resistant to antibiotics", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220X (13 March 2024); https://doi.org/10.1117/12.3004522

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