Nano-pulsed laser therapy (NPLT) for clearance of AD-related toxic oligomers

Kevin J. Johnson; Auston C. Grant; Kathia M. Johnson; Rinat O. Esenaliev; Giulio Taglialatela; Maria-Adelaide Micci

doi:10.1117/12.3008996

13 March 2024 Nano-pulsed laser therapy (NPLT) for clearance of AD-related toxic oligomers

Kevin J. Johnson, Auston C. Grant, Kathia M. Johnson, Rinat O. Esenaliev, Giulio Taglialatela, Maria-Adelaide Micci

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284225 (2024) https://doi.org/10.1117/12.3008996
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Synaptic dysfunction driven by toxic amyloid Aβ oligomers (Aβo) is one of the early events in Alzheimer’s disease (AD) leading to cognitive decline, disability, and death. We have shown that optoacoustic therapy/NPLT can be used for traumatic brain injury (TBI) treatment. We have also shown that mature neurons generated from the NPLT-treated rat hippocampal neural stem cells (NSCs) had significantly lower Aβo levels. Here we used a custom-made 808-nm optoacoustic system to study autophagy pathways changes induced by NPLT. Our results suggest that autophagy pathways are upregulated in NPLT-treated NSCs compared to sham which could lead to enhanced Aβo clearance.

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Kevin J. Johnson, Auston C. Grant, Kathia M. Johnson, Rinat O. Esenaliev, Giulio Taglialatela, and Maria-Adelaide Micci "Nano-pulsed laser therapy (NPLT) for clearance of AD-related toxic oligomers", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284225 (13 March 2024); https://doi.org/10.1117/12.3008996

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