Surface enhanced Raman sensing with sculptured thin film dispersion gel

Motofumi Suzuki; Takao Fukuoka; Ryutaro Ohnishi; Taiga Taneichi; Kota Tokunaga; Misa Kanagawa; Samir Kumar; Kyoko Namura

doi:10.1117/12.3027564

4 October 2024 Surface enhanced Raman sensing with sculptured thin film dispersion gel

Motofumi Suzuki, Takao Fukuoka, Ryutaro Ohnishi, Taiga Taneichi, Kota Tokunaga, Misa Kanagawa, Samir Kumar, Kyoko Namura

Author Affiliations +

Proceedings Volume PC13116, Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XXI; PC1311603 (2024) https://doi.org/10.1117/12.3027564
Event: Nanoscience + Engineering, 2024, San Diego, California, United States

Abstract

We have developed a gel-type surface-enhanced Raman scattering (SERS) sensor for the direct extraction of biomarkers from human skin and other sources. First, We used SERS-active sculptured Au nanoparticle substrates to explore how molecules move within hydroxyethyl cellulose (HEC) gels. This investigation aimed to understand the transport of biomarkers in gels and the feasibility of detecting them using SERS. Notably, the results revealed that HEC gels do not hinder SERS sensing. Additionally, the diffusion coefficient within the gels was found to be dependent on the molecular weight of the biomarkers. Then, we fabricated SERS-active sculptured thin-film dispersion gels by creating multilayer structures on mica. These multilayer structures significantly improved SERS performance due to the light confinement effect. Subsequently, we dispersed milled flakes into the gel. The resulting SERS-active flake dispersion gel holds promise for biosensing applications. Specifically, it allows for the direct collection of body fluids, such as sweat, from human skin.

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Citation Download Citation

Motofumi Suzuki, Takao Fukuoka, Ryutaro Ohnishi, Taiga Taneichi, Kota Tokunaga, Misa Kanagawa, Samir Kumar, and Kyoko Namura "Surface enhanced Raman sensing with sculptured thin film dispersion gel", Proc. SPIE PC13116, Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XXI, PC1311603 (4 October 2024); https://doi.org/10.1117/12.3027564

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KEYWORDS

Raman spectroscopy

Surface enhanced Raman spectroscopy

Cellulose

Electromagnetism

Molecular spectroscopy

Molecules

Multilayers

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