Noninvasive Raman tomographic imaging of canine bone tissue

Matthew V. Schulmerich; Jacqueline H. Cole; Kathryn A. Dooley; Michael D. Morris; Jaclynn Kreider; Steven A. Goldstein; Subhadra Srinivasan; Brian W. Pogue

doi:10.1117/1.2904940

1 March 2008 Noninvasive Raman tomographic imaging of canine bone tissue

Matthew V. Schulmerich, Jacqueline H. Cole, Kathryn A. Dooley, Michael D. Morris, Jaclynn Kreider, Steven A. Goldstein, Subhadra Srinivasan, Brian W. Pogue

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Journal of Biomedical Optics, Vol. 13, Issue 2, 020506 (March 2008). https://doi.org/10.1117/1.2904940

Abstract

Raman spectroscopic diffuse tomographic imaging has been demonstrated for the first time. It provides a noninvasive, label-free modality to image the chemical composition of human and animal tissue and other turbid media. This technique has been applied to image the composition of bone tissue within an intact section of a canine limb. Spatially distributed 785-nm laser excitation was employed to prevent thermal damage to the tissue. Diffuse emission tomography reconstruction was used, and the location that was recovered has been confirmed by micro-computed tomography (micro-CT) images.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Matthew V. Schulmerich, Jacqueline H. Cole, Kathryn A. Dooley, Michael D. Morris, Jaclynn Kreider, Steven A. Goldstein, Subhadra Srinivasan, and Brian W. Pogue "Noninvasive Raman tomographic imaging of canine bone tissue," Journal of Biomedical Optics 13(2), 020506 (1 March 2008). https://doi.org/10.1117/1.2904940

Published: 1 March 2008

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