Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data

Jia Wang; Scott C. Davis; Subhadra Srinivasan; Shudong Jiang; Brian W. Pogue; Keith D. Paulsen

doi:10.1117/1.2952006

1 July 2008 Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data

Jia Wang, Scott C. Davis, Subhadra Srinivasan, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen

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Journal of Biomedical Optics, Vol. 13, Issue 4, 041305 (July 2008). https://doi.org/10.1117/1.2952006

Abstract

Near-infrared (NIR) region-based spectroscopy is examined for accuracy with spectral recovery using frequency domain data at a discrete number of wavelengths, as compared to that with broadband continuous wave data. Data with more wavelengths in the frequency domain always produce superior quantitative spectroscopy results with reduced noise and error in the chromophore concentrations. Performance of the algorithm in the situation of doing region-guided spectroscopy within the MRI is also considered, and the issue of false positive prior regions being identified is examined to see the effect of added wavelengths. The results indicate that broadband frequency domain data are required for maximal accuracy. A broadband frequency domain experimental system was used to validate the predictions, using a mode-locked Ti:sapphire laser for the source between 690- and 850-nm wavelengths. The 80-MHz pulsed signal is heterodyned with photomultiplier tube detection, to lower frequency for data acquisition. Tissue-phantom experiments with known hemoglobin absorption and tissue-like scatter values are used to validate the system, using measurements every 10 nm. More wavelengths clearly provide superior quantification of total hemoglobin values. The system and algorithms developed here should provide an optimal way to quantify regions with the goal of image-guided breast tissue spectroscopy within the MRI.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Jia Wang, Scott C. Davis, Subhadra Srinivasan, Shudong Jiang, Brian W. Pogue, and Keith D. Paulsen "Spectral tomography with diffuse near-infrared light: inclusion of broadband frequency domain spectral data," Journal of Biomedical Optics 13(4), 041305 (1 July 2008). https://doi.org/10.1117/1.2952006

Published: 1 July 2008

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