Monte Carlo modeling of multilayer phantoms with multiple fluorophores: simulation algorithm and experimental validation

Emilie Pery; Walter C. P. M. Blondel; Cedric Thomas; François H. Guillemin M.D.

doi:10.1117/1.3122368

1 March 2009 Monte Carlo modeling of multilayer phantoms with multiple fluorophores: simulation algorithm and experimental validation

Emilie Pery, Walter C. P. M. Blondel, Cedric Thomas, François H. Guillemin M.D.

Author Affiliations +

Journal of Biomedical Optics, Vol. 14, Issue 2, 024048 (March 2009). https://doi.org/10.1117/1.3122368

Abstract

This work is first a description of a statistical simulation algorithm developed for simulating the spectral absorption and emission of several fluorophores in an absorbing and diffusing multilayer model. Second, a detailed experimental validation of the simulation program is conducted on two sets of liquid and solid multilayer phantoms, containing one, two, or three fluorophores, within absorbing and scattering media. Experimental spatially resolved reflectance spectra are acquired in the wavelength band 400 to 800 nm and compared to corresponding simulated spectra. The degree of similarity between experimentation and simulation data is quantified. The results obtained underline good correlations with mean errors varying from 2 to 10%, depending on the number of layers and on the complexity of the phantom's composition.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Emilie Pery, Walter C. P. M. Blondel, Cedric Thomas, and François H. Guillemin M.D. "Monte Carlo modeling of multilayer phantoms with multiple fluorophores: simulation algorithm and experimental validation," Journal of Biomedical Optics 14(2), 024048 (1 March 2009). https://doi.org/10.1117/1.3122368

Published: 1 March 2009

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KEYWORDS

Monte Carlo methods

Luminescence

Absorption

Tissues

Computer simulations

Algorithm development

Solids

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