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1 August 2011 Habits with killer instincts: in vivo analysis on the severity of oral mucosal alterations using autofluorescence spectroscopy
S. Nazaeer Shaiju, Saraswathy Ariya, Ramapurath S. Jayasree, Rajasekharan Asish, Padippurakkakath S. Haris, Balan Anita, Gupta A. Kumar
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Journal of Biomedical Optics, Vol. 16, Issue 8, 087006 (August 2011). https://doi.org/10.1117/1.3608923
Abstract
Oral habits like chewing and smoking are main causes of oral cancer, which has a higher mortality rate than many other cancer forms. Currently, the long term survival rate of oral cancer is less than 50%, as a majority of cases are detected very late. The clinician's main challenge is to differentiate among a multitude of red, white, or ulcerated lesions. Hence, new noninvasive, reliable, and fast techniques for the discrimination of oral cavity disorders are to be developed. This study includes autofluorescence spectroscopic screening of normal volunteers with and without lifestyle oral habits and patients with oral submucous fibrosis (OSF). The spectra from different sites of habitués, non-habitués, and OSF patients were analyzed using the intensity ratio, redox ratio, and linear discriminant analysis (LDA). The spectral disparities among these groups are well demonstrated in the emission regions of collagen and Flavin adenine dinucleotide. We observed that LDA gives better efficiency of classification than the intensity ratio technique. Even the differentiation of habitués and non-habitués could be well established with LDA. The study concludes that the clinical application of autofluorescence spectroscopy along with LDA, yields spontaneous screening among individuals, facilitating better patient management for clinicians and better quality of life for patients.
©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
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S. Nazaeer Shaiju, Saraswathy Ariya, Ramapurath S. Jayasree, Rajasekharan Asish, Padippurakkakath S. Haris, Balan Anita, and Gupta A. Kumar "Habits with killer instincts: in vivo analysis on the severity of oral mucosal alterations using autofluorescence spectroscopy," Journal of Biomedical Optics 16(8), 087006 (1 August 2011). https://doi.org/10.1117/1.3608923
Published: 1 August 2011
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Cited by 26 scholarly publications.
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KEYWORDS
Collagen
Cancer
In vivo imaging
Luminescence
Biological research
Spectroscopy
Tissues
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