Flux density calibration in diffuse optical tomographic systems

Samir Kumar Biswas; Kanhirodan Rajan; Ram Vasu

doi:10.1117/1.JBO.18.2.026023

19 February 2013 Flux density calibration in diffuse optical tomographic systems

Samir Kumar Biswas, Kanhirodan Rajan, Ram Vasu

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Funded by: Department of Science and Technology

Journal of Biomedical Optics, Vol. 18, Issue 2, 026023 (February 2013). https://doi.org/10.1117/1.JBO.18.2.026023

Abstract

The solution of the forward equation that models the transport of light through a highly scattering tissue material in diffuse optical tomography (DOT) using the finite element method gives flux density (Φ ) at the nodal points of the mesh. The experimentally measured flux (U measured ) on the boundary over a finite surface area in a DOT system has to be corrected to account for the system transfer functions (R) of various building blocks of the measurement system. We present two methods to compensate for the perturbations caused by R and estimate true flux density (Φ ) from U cal measured . In the first approach, the measurement data with a homogeneous phantom (U homo measured ) is used to calibrate the measurement system. The second scheme estimates the homogeneous phantom measurement using only the measurement from a heterogeneous phantom, thereby eliminating the necessity of a homogeneous phantom. This is done by statistically averaging the data (U hetero measured ) and redistributing it to the corresponding detector positions. The experiments carried out on tissue mimicking phantom with single and multiple inhomogeneities, human hand, and a pork tissue phantom demonstrate the robustness of the approach.

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Samir Kumar Biswas, Kanhirodan Rajan, and Ram Vasu "Flux density calibration in diffuse optical tomographic systems," Journal of Biomedical Optics 18(2), 026023 (19 February 2013). https://doi.org/10.1117/1.JBO.18.2.026023

Published: 19 February 2013

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