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22 December 2014 In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging
Muyinatu A. Lediju Bell, Nathanael P. Kuo, Danny Y. Song M.D., Jin U. Kang, Emad M. Boctor
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Journal of Biomedical Optics, Vol. 19, Issue 12, 126011 (December 2014). https://doi.org/10.1117/1.JBO.19.12.126011
Abstract
We conducted a canine study to investigate the in vivo feasibility of photoacoustic imaging for intraoperative updates to brachytherapy treatment plans. A fiber coupled to a 1064-nm Nd:YAG laser was inserted into high-dose-rate brachytherapy needles, which diffused light spherically. These needles were inserted through the perineum into the prostate for interstitial light delivery and the resulting acoustic waves were detected with a transrectal ultrasound probe. Postoperative computed tomography images and ex vivo photoacoustic images confirmed seed locations. Limitations with insufficient light delivery were mitigated with short-lag spatial coherence (SLSC) beamforming, providing a 10–20 dB contrast improvement over delay-and-sum (DAS) beamforming for pulse energies ranging from 6.8 to 10.5 mJ with a fiber-seed distance as large as 9.5 mm. For the same distance and the same range of energy densities, signal-to-noise ratios (SNRs) were similar while the contrast-to-noise ratio (CNR) was higher in SLSC compared to DAS images. Challenges included visualization of signals associated with the interstitial fiber tip and acoustic reverberations between seeds separated by ≤2 mm. Results provide insights into the potential for clinical translation to humans.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Muyinatu A. Lediju Bell, Nathanael P. Kuo, Danny Y. Song M.D., Jin U. Kang, and Emad M. Boctor "In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging," Journal of Biomedical Optics 19(12), 126011 (22 December 2014). https://doi.org/10.1117/1.JBO.19.12.126011
Published: 22 December 2014
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Cited by 101 scholarly publications and 1 patent.
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KEYWORDS
Prostate
Photoacoustic spectroscopy
Ultrasonography
Visualization
In vivo imaging
Photoacoustic imaging
Computed tomography
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