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28 May 2014 Noninvasive assessment of the risk of tobacco abuse in oral mucosa using fluorescence spectroscopy: a clinical approach
Shaiju S. Nazeer, Rajashekharan Asish, Chandrashekharan Venugopal, Balan Anita, Arun Kumar Gupta, Ramapurath S. Jayasree
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Journal of Biomedical Optics, Vol. 19, Issue 5, 057013 (May 2014). https://doi.org/10.1117/1.JBO.19.5.057013
Abstract
Tobacco abuse and alcoholism cause cancer, emphysema, and heart disease, which contribute to high death rates, globally. Society pays a significant cost for these habits whose first demonstration in many cases is in the oral cavity. Oral cavity disorders are highly curable if a screening procedure is available to diagnose them in the earliest stages. The aim of the study is to identify the severity of tobacco abuse, in oral cavity, as reflected by the emission from endogenous fluorophores and the chromophore hemoglobin. A group who had no tobacco habits and another with a history of tobacco abuse were included in this study. To compare the results with a pathological condition, a group of leukoplakia patients were also included. Emission from porphyrin and the spectral filtering modulation effect of hemoglobin were collected from different sites. Multivariate analysis strengthened the spectral features with a sensitivity of 60% to 100% and a specificity of 76% to 100% for the discrimination. Total hemoglobin and porphyrin levels of habitués and leukoplakia groups were comparable, indicating the alarming situation about the risk of tobacco abuse. Results prove that fluorescence spectroscopy along with multivariate analysis is an effective noninvasive tool for the early diagnosis of pathological changes due to tobacco abuse.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2014/$25.00 © 2014 SPIE
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Shaiju S. Nazeer, Rajashekharan Asish, Chandrashekharan Venugopal, Balan Anita, Arun Kumar Gupta, and Ramapurath S. Jayasree "Noninvasive assessment of the risk of tobacco abuse in oral mucosa using fluorescence spectroscopy: a clinical approach," Journal of Biomedical Optics 19(5), 057013 (28 May 2014). https://doi.org/10.1117/1.JBO.19.5.057013
Published: 28 May 2014
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Cited by 21 scholarly publications.
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KEYWORDS
Tissues
Fluorescence spectroscopy
Cancer
Luminescence
Principal component analysis
Fiber optics
Mouth
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