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14 October 2015 Diffuse photon density wave measurements and Monte Carlo simulations
Vladimir L. Kuzmin, Michael T. Neidrauer, David Diaz, Leonid A. Zubkov
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Journal of Biomedical Optics, Vol. 20, Issue 10, 105006 (October 2015). https://doi.org/10.1117/1.JBO.20.10.105006
Abstract
Diffuse photon density wave (DPDW) methodology is widely used in a number of biomedical applications. Here, we present results of Monte Carlo simulations that employ an effective numerical procedure based upon a description of radiative transfer in terms of the Bethe–Salpeter equation. A multifrequency noncontact DPDW system was used to measure aqueous solutions of intralipid at a wide range of source–detector separation distances, at which the diffusion approximation of the radiative transfer equation is generally considered to be invalid. We find that the signal–noise ratio is larger for the considered algorithm in comparison with the conventional Monte Carlo approach. Experimental data are compared to the Monte Carlo simulations using several values of scattering anisotropy and to the diffusion approximation. Both the Monte Carlo simulations and diffusion approximation were in very good agreement with the experimental data for a wide range of source–detector separations. In addition, measurements with different wavelengths were performed to estimate the size and scattering anisotropy of scatterers.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
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Vladimir L. Kuzmin, Michael T. Neidrauer, David Diaz, and Leonid A. Zubkov "Diffuse photon density wave measurements and Monte Carlo simulations," Journal of Biomedical Optics 20(10), 105006 (14 October 2015). https://doi.org/10.1117/1.JBO.20.10.105006
Published: 14 October 2015
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Cited by 17 scholarly publications.
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KEYWORDS
Monte Carlo methods
Scattering
Sensors
Diffusion
Modulation
Diffuse photon density waves
Anisotropy
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