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11 March 2015 Overview of single-cell elastic light scattering techniques
Matti Kinnunen, Artashes Karmenyan
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Journal of Biomedical Optics, Vol. 20, Issue 5, 051040 (March 2015). https://doi.org/10.1117/1.JBO.20.5.051040
Abstract
We present and discuss several modern optical methods based on elastic light scattering (ELS), along with their technical features and applications in biomedicine and life sciences. In particular, we review some ELS experiments at the single-cell level and explore new directions of applications. Due to recent developments in experimental systems (as shown in the literature), ELS lends itself to useful applications in the life sciences. Of the developed methods, we cover elastic scattering spectroscopy, optical tweezer-assisted measurement, goniometers, Fourier transform light scattering (FTLS), and microscopic methods. FTLS significantly extends the potential analysis of single cells by allowing monitoring of dynamical changes at the single-cell level. The main aim of our review is to demonstrate developments in the experimental investigation of ELS in single cells including issues related to theoretical “representations” and modeling of biological systems (cells, cellular systems, tissues, and so on). Goniometric measurements of ELS from optically trapped single cells are shown and the importance of the experimental verification of theoretical models of ELS in the context of biomedical applications is discussed.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Matti Kinnunen and Artashes Karmenyan "Overview of single-cell elastic light scattering techniques," Journal of Biomedical Optics 20(5), 051040 (11 March 2015). https://doi.org/10.1117/1.JBO.20.5.051040
Published: 11 March 2015
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Cited by 16 scholarly publications and 2 patents.
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KEYWORDS
Light scattering
Electrophoretic light scattering
Scattering
Particles
Laser scattering
Refractive index
Flow cytometry
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