Open Access
3 September 2015 Assessing the sensitivity of human skin hyperspectral responses to increasing anemia severity levels
Gladimir V. G. Baranoski, Ankita Dey, Tenn F. Chen
Author Affiliations +
Funded by: Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology), Natural Sciences and Research Council of Canada (NSERC)
Abstract
Anemia is a prevalent medical condition that seriously affects millions of people all over the world. In many regions, not only its initial detection but also its monitoring are hindered by limited access to laboratory facilities. This situation has motivated the development of a wide range of optical devices and procedures to assist physicians in these tasks. Although noticeable progress has been achieved in this area, the search for reliable, low-cost, and risk-free solutions still continues, and the strengthening of the knowledge base about this disorder and its effects is essential for the success of these initiatives. We contribute to these efforts by closely examining the sensitivity of human skin hyperspectral responses (within and outside the visible region of the light spectrum) to reduced hemoglobin concentrations associated with increasing anemia severity levels. This investigation, which involves skin specimens with distinct biophysical and morphological characteristics, is supported by controlled in silico experiments performed using a predictive light transport model and measured data reported in the biomedical literature. We also propose a noninvasive procedure to be employed in the monitoring of this condition at the point-of-care.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Gladimir V. G. Baranoski, Ankita Dey, and Tenn F. Chen "Assessing the sensitivity of human skin hyperspectral responses to increasing anemia severity levels," Journal of Biomedical Optics 20(9), 095002 (3 September 2015). https://doi.org/10.1117/1.JBO.20.9.095002
Published: 3 September 2015
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CITATIONS
Cited by 10 scholarly publications and 1 patent.
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KEYWORDS
Skin

Reflectivity

Blood

Data modeling

Visible radiation

Tissues

Magnesium

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