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11 May 2016 From Jöbsis to the present day: a review of clinical near-infrared spectroscopy measurements of cerebral cytochrome-c-oxidase
Gemma Bale, Clare E. Elwell, Ilias Tachtsidis
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Journal of Biomedical Optics, Vol. 21, Issue 9, 091307 (May 2016). https://doi.org/10.1117/1.JBO.21.9.091307
Abstract
Near-infrared spectroscopy (NIRS) measurements of cytochrome-c-oxidase (CCO) have the potential to yield crucial information about cerebral metabolism at the patient bedside. Developments in instrumentation and the analytical methods used to resolve changes in CCO have led to many clinical applications of the measurement since its first demonstration in 1977 by Jöbsis. There is a substantial literature of work on measures of CCO in animal and in vitro studies; however, this review focuses on translational studies. Almost 40 years from the advent of the first measurement of CCO using NIRS, this signal continues to hold significant interest in our understanding of the human brain in health and disease. We discuss methodologies for obtaining NIRS measurements of CCO in the clinic and review studies in neonates and adults.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Gemma Bale, Clare E. Elwell, and Ilias Tachtsidis "From Jöbsis to the present day: a review of clinical near-infrared spectroscopy measurements of cerebral cytochrome-c-oxidase," Journal of Biomedical Optics 21(9), 091307 (11 May 2016). https://doi.org/10.1117/1.JBO.21.9.091307
Published: 11 May 2016
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Cited by 158 scholarly publications and 1 patent.
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KEYWORDS
Near infrared spectroscopy
Brain
Oxygen
Mode conditioning cables
Signal attenuation
Tissue optics
Chromophores
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