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27 October 2017 Multifocal spectral-domain optical coherence tomography based on Bessel beam for extended imaging depth
Luying Yi, Liqun Sun, Wuwen Ding
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Funded by: State Key Lab Precision Measurement Technology and Instruments, Tsinghua University, National Major Scientific Instrument and Equipment Development Project of China
Journal of Biomedical Optics, Vol. 22, Issue 10, 106016 (October 2017). https://doi.org/10.1117/1.JBO.22.10.106016
Abstract
To advance the practical application of optical coherence tomography (OCT) in the field of biomedical imaging, the imaging depth must be extended without sacrificing resolution while maintaining sufficient sensitivity. However, there is an inherent trade-off between lateral resolution and depth of field (DOF) in OCT. To address this shortcoming, this article proposes a multifocal Bessel beam spectral-domain optical coherence tomography (MBSDOCT) capable of increasing the DOF with unchanged lateral resolution and a high signal-to-noise ratio. The proposed technique is demonstrated by simulation and experiment. A three-focal MBSDOCT with an axicon lens theoretically achieved a DOF of ∼6  mm with a lateral resolution of ∼13  μm. In imaging experiments performed on the acinar cells of orange tissue, a measured DOF of ∼4  mm was demonstrated with a sensitivity penalty of ∼18.1  dB, relative to the Gaussian beam spectral-domain OCT, with a 9-mW light source.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Luying Yi, Liqun Sun, and Wuwen Ding "Multifocal spectral-domain optical coherence tomography based on Bessel beam for extended imaging depth," Journal of Biomedical Optics 22(10), 106016 (27 October 2017). https://doi.org/10.1117/1.JBO.22.10.106016
Received: 14 July 2017; Accepted: 11 October 2017; Published: 27 October 2017
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KEYWORDS
Optical coherence tomography
Signal to noise ratio
Bessel beams
Axicons
Image resolution
Sun
Gaussian beams
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