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20 February 2017 Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument
Manmohan Singh, Zhaolong Han, Achuth Nair, Alexander Schill, Michael D. Twa, Kirill V. Larin
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Journal of Biomedical Optics, Vol. 22, Issue 2, 020502 (February 2017). https://doi.org/10.1117/1.JBO.22.2.020502
Abstract
Current clinical tools provide critical information about ocular health such as intraocular pressure (IOP). However, they lack the ability to quantify tissue material properties, which are potent markers for ocular tissue health and integrity. We describe a single instrument to measure the eye-globe IOP, quantify corneal biomechanical properties, and measure corneal geometry with a technique termed applanation optical coherence elastography (Appl-OCE). An ultrafast OCT system enabled visualization of corneal dynamics during noncontact applanation tonometry and direct measurement of micro air-pulse induced elastic wave propagation. Our preliminary results show that the proposed Appl-OCE system can be used to quantify IOP, corneal biomechanical properties, and corneal geometry, which builds a solid foundation for a unique device that can provide a more complete picture of ocular health.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2016/$25.00 © 2016 SPIE
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Manmohan Singh, Zhaolong Han, Achuth Nair, Alexander Schill, Michael D. Twa, and Kirill V. Larin "Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument," Journal of Biomedical Optics 22(2), 020502 (20 February 2017). https://doi.org/10.1117/1.JBO.22.2.020502
Received: 8 November 2016; Accepted: 30 January 2017; Published: 20 February 2017
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Cited by 15 scholarly publications.
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KEYWORDS
Cornea
Optical coherence tomography
Elastography
Coherence (optics)
Tissues
Wave propagation
Video
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