In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra

Yuan Qu; Peng Hu; Junhui Shi; Konstantin Maslov; Peinan Zhao; Chiye Li; Jun Ma; Alejandro Garcia-Uribe; Karen Meyers; Emily Diveley; Stephanie Pizzella; Lisa Muench; Nina Punyamurthy; Naomi Goldstein; Oji Onwumere; Mariana Alisio; Kaytelyn Meyenburg; Jennifer Maynard; Kristi Helm; Emma Altieri; Janessia Slaughter; Sabrina Barber; Tracy Burger; Christine Kramer; Jessica Chubiz; Monica Anderson; Ronald McCarthy; Sarah K. England; George A. Macones; Molly J. Stout M.D.; Methodius Tuuli; Lihong V. Wang

doi:10.1117/1.JBO.23.12.121621

5 December 2018 In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra

Yuan Qu, Peng Hu, Junhui Shi, Konstantin Maslov, Peinan Zhao, Chiye Li, Jun Ma, Alejandro Garcia-Uribe, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Emma Altieri, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald McCarthy, Sarah K. England, George A. Macones, Molly J. Stout M.D., Methodius Tuuli, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 23, Issue 12, 121621 (December 2018). https://doi.org/10.1117/1.JBO.23.12.121621

Abstract

Premature cervical remodeling is a critical precursor of spontaneous preterm birth, and the remodeling process is characterized by an increase in tissue hydration. Nevertheless, current clinical measurements of cervical remodeling are subjective and detect only late events, such as cervical effacement and dilation. Here, we present a photoacoustic endoscope that can quantify tissue hydration by measuring near-infrared cervical spectra. We quantify the water contents of tissue-mimicking hydrogel phantoms as an analog of cervical connective tissue. Applying this method to pregnant women in vivo, we observed an increase in the water content of the cervix throughout pregnancy. The application of this technique in maternal healthcare may advance our understanding of cervical remodeling and provide a sensitive method for predicting preterm birth.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Yuan Qu, Peng Hu, Junhui Shi, Konstantin Maslov, Peinan Zhao, Chiye Li, Jun Ma, Alejandro Garcia-Uribe, Karen Meyers, Emily Diveley, Stephanie Pizzella, Lisa Muench, Nina Punyamurthy, Naomi Goldstein, Oji Onwumere, Mariana Alisio, Kaytelyn Meyenburg, Jennifer Maynard, Kristi Helm, Emma Altieri, Janessia Slaughter, Sabrina Barber, Tracy Burger, Christine Kramer, Jessica Chubiz, Monica Anderson, Ronald McCarthy, Sarah K. England, George A. Macones, Molly J. Stout M.D., Methodius Tuuli, and Lihong V. Wang "In vivo characterization of connective tissue remodeling using infrared photoacoustic spectra," Journal of Biomedical Optics 23(12), 121621 (5 December 2018). https://doi.org/10.1117/1.JBO.23.12.121621

Received: 26 August 2018; Accepted: 14 November 2018; Published: 5 December 2018

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY