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12 April 2018 Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models
Pouya Jelvehgaran, Daniel Martijn de Bruin, F. Javier Salguero, Gerben Roelof Borst, Ji-Ying Song, Ton G. van Leeuwen, Johannes F. de Boer, Tanja Alderliesten, Marcel B. van Herk
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Funded by: Netherlands Organization for Health Research and Development (ZonMw), Elekta Ltd., NinePoint Medical, Inc.
Journal of Biomedical Optics, Vol. 23, Issue 4, 046004 (April 2018). https://doi.org/10.1117/1.JBO.23.4.046004
Abstract
Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10  μm) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose delivery of 4.0, 10.0, 16.0, and 20.0 Gy on 5.0-mm spots, spaced 10.0 mm apart in the esophagus. They were repeatedly imaged using OCT up to three months postirradiation. We compared OCT findings with histopathology obtained three months postirradiation qualitatively and quantitatively using the contrast-to-background-noise ratio (CNR). Histopathology mostly showed inflammatory infiltration and edema at higher doses; OCT findings were in agreement with most of the histopathological reports. We were able to identify the ARIED on OCT as a change in tissue scattering and layer thickness. Our statistical analysis showed significant difference between the CNR values of healthy tissue, edema, and inflammatory infiltration. Overall, the average CNR for inflammatory infiltration and edema damages was 1.6-fold higher and 1.6-fold lower than for the healthy esophageal wall, respectively. Our results showed the potential role of OCT to detect and monitor the ARIED in mice, which may translate to humans.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Pouya Jelvehgaran, Daniel Martijn de Bruin, F. Javier Salguero, Gerben Roelof Borst, Ji-Ying Song, Ton G. van Leeuwen, Johannes F. de Boer, Tanja Alderliesten, and Marcel B. van Herk "Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models," Journal of Biomedical Optics 23(4), 046004 (12 April 2018). https://doi.org/10.1117/1.JBO.23.4.046004
Received: 11 November 2017; Accepted: 26 March 2018; Published: 12 April 2018
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Cited by 12 scholarly publications.
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KEYWORDS
Optical coherence tomography
Esophagus
Tissues
Scattering
Computed tomography
In vivo imaging
Visualization
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