Automated segmentation of geographic atrophy in fundus autofluorescence images using supervised pixel classification

Zhihong Hu; Gerard G. Medioni; Matthias Hernandez; Srinivas  R. Sadda

doi:10.1117/1.JMI.2.1.014501

12 January 2015 Automated segmentation of geographic atrophy in fundus autofluorescence images using supervised pixel classification

Zhihong Hu, Gerard G. Medioni, Matthias Hernandez, Srinivas R. Sadda

Author Affiliations +

Journal of Medical Imaging, Vol. 2, Issue 1, 014501 (January 2015). https://doi.org/10.1117/1.JMI.2.1.014501

Abstract

Geographic atrophy (GA) is a manifestation of the advanced or late stage of age-related macular degeneration (AMD). AMD is the leading cause of blindness in people over the age of 65 in the western world. The purpose of this study is to develop a fully automated supervised pixel classification approach for segmenting GA, including uni- and multifocal patches in fundus autofluorescene (FAF) images. The image features include region-wise intensity measures, gray-level co-occurrence matrix measures, and Gaussian filter banks. A k-nearest-neighbor pixel classifier is applied to obtain a GA probability map, representing the likelihood that the image pixel belongs to GA. Sixteen randomly chosen FAF images were obtained from 16 subjects with GA. The algorithm-defined GA regions are compared with manual delineation performed by a certified image reading center grader. Eight-fold cross-validation is applied to evaluate the algorithm performance. The mean overlap ratio (OR), area correlation (Pearson’s r), accuracy (ACC), true positive rate (TPR), specificity (SPC), positive predictive value (PPV), and false discovery rate (FDR) between the algorithm- and manually defined GA regions are 0.72±0.03, 0.98±0.02, 0.94±0.00, 0.87±0.01, 0.96±0.01, 0.80±0.04, and 0.20±0.04, respectively.

Citation Download Citation

Zhihong Hu, Gerard G. Medioni, Matthias Hernandez, and Srinivas R. Sadda "Automated segmentation of geographic atrophy in fundus autofluorescence images using supervised pixel classification," Journal of Medical Imaging 2(1), 014501 (12 January 2015). https://doi.org/10.1117/1.JMI.2.1.014501

Published: 12 January 2015

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