Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep

Peyman Zirak; Clara Gregori-Pla; Igor Blanco; Ana Fortuna M.D.; Gianluca Cotta; Pau Bramon; Isabel Serra; Anna Mola M.D.; Jordi Solà-Soler; Beatriz F. Giraldo-Giraldo; Turgut Durduran; Mercedes Mayos

doi:10.1117/1.NPh.5.4.045003

3 November 2018 Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep

Peyman Zirak, Clara Gregori-Pla, Igor Blanco, Ana Fortuna M.D., Gianluca Cotta, Pau Bramon, Isabel Serra, Anna Mola M.D., Jordi Solà-Soler, Beatriz F. Giraldo-Giraldo, Turgut Durduran, Mercedes Mayos

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Neurophotonics, Vol. 5, Issue 4, 045003 (November 2018). https://doi.org/10.1117/1.NPh.5.4.045003

Abstract

Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may improve our knowledge of these consequences and then allow for the development of preventive strategies. Our aim was to characterize the typical microvascular, cortical cerebral blood flow (CBF) changes in an OSA population during an apneic event. Sixteen patients (age 58 ± 8 years, 75% male) with a high risk of severe OSA were measured with a polysomnography device and with diffuse correlation spectroscopy (DCS) during one night of sleep with 1365 obstructive apneic events detected. All patients were later confirmed to suffer from severe OSA syndrome with a mean of 83 ± 15 apneas and hypopneas per hour. DCS has been shown to be able to characterize the microvascular CBF response to each event with a sufficient contrast-to-noise ratio to reveal its dynamics. It has also revealed that an apnea causes a peak increase of microvascular CBF (30 ± 17 % ) at the end of the event followed by a drop (−20 ± 12 % ) similar to what was observed in macrovascular CBF velocity of the middle cerebral artery. This study paves the way for the utilization of DCS for further studies on these populations.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Peyman Zirak, Clara Gregori-Pla, Igor Blanco, Ana Fortuna M.D., Gianluca Cotta, Pau Bramon, Isabel Serra, Anna Mola M.D., Jordi Solà-Soler, Beatriz F. Giraldo-Giraldo, Turgut Durduran, and Mercedes Mayos "Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep," Neurophotonics 5(4), 045003 (3 November 2018). https://doi.org/10.1117/1.NPh.5.4.045003

Received: 9 June 2018; Accepted: 10 October 2018; Published: 3 November 2018

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