Simple device for the direct visualization of oral-cavity tissue fluorescence

Pierre Mark Lane; Terence Gilhuly; Peter D. Whitehead; Haishan Zeng; Catherine Poh; Samson Ng; Michelle Williams; Lewei Zhang; Miriam Rosin; Calum E. MacAulay

doi:10.1117/1.2193157

1 March 2006 Simple device for the direct visualization of oral-cavity tissue fluorescence

Pierre Mark Lane, Terence Gilhuly, Peter D. Whitehead, Haishan Zeng, Catherine Poh, Samson Ng, Michelle Williams, Lewei Zhang, Miriam Rosin, Calum E. MacAulay

Author Affiliations +

Journal of Biomedical Optics, Vol. 11, Issue 2, 024006 (March 2006). https://doi.org/10.1117/1.2193157

Abstract

Early identification of high-risk disease could greatly reduce both mortality and morbidity due to oral cancer. We describe a simple handheld device that facilitates the direct visualization of oral-cavity fluorescence for the detection of high-risk precancerous and early cancerous lesions. Blue excitation light (400 to 460 nm) is employed to excite green-red fluorescence from fluorophores in the oral tissues. Tissue fluorescence is viewed directly along an optical axis collinear with the axis of excitation to reduce inter- and intraoperator variability. This robust, field-of-view device enables the direct visualization of fluorescence in the context of surrounding normal tissue. Results from a pilot study of 44 patients are presented. Using histology as the gold standard, the device achieves a sensitivity of 98% and specificity of 100% when discriminating normal mucosa from severe dysplasia/carcinoma in situ (CIS) or invasive carcinoma. We envisage this device as a suitable adjunct for oral cancer screening, biopsy guidance, and margin delineation.

©(2006) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Pierre Mark Lane, Terence Gilhuly, Peter D. Whitehead, Haishan Zeng, Catherine Poh, Samson Ng, Michelle Williams, Lewei Zhang, Miriam Rosin, and Calum E. MacAulay "Simple device for the direct visualization of oral-cavity tissue fluorescence," Journal of Biomedical Optics 11(2), 024006 (1 March 2006). https://doi.org/10.1117/1.2193157

Published: 1 March 2006

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 338 scholarly publications and 6 patents.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Luminescence

Visualization

Tissues

Cancer

Tissue optics

Biopsy

Optical filters

Show All Keywords

RELATED CONTENT

Optical biopsy using fluorescence spectroscopy for prostate cancer diagnosis
Proceedings of SPIE (February 13 2017)

Fluorescence influence on screening decisions for oral cancer
Proceedings of SPIE (August 10 2018)

Micro image mosaicking for video rate multi channel fluorescence microendoscopy...
Proceedings of SPIE (January 01 1900)

Endogenous fluorescence new approach to in situ detection of...
Proceedings of SPIE (June 01 2005)

Fluorescence-guided surgical resection of oral cancer reduces recurrence
Proceedings of SPIE (February 17 2011)

The photodynamic detection of mucosal abnormality in oral cancer patients...
Proceedings of SPIE (March 23 2005)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years