Empirical model description of photon path length for differential path length spectroscopy: combined effect of scattering and absorption

Stephen Chad Kanick; Henricus J. C. M. Sterenborg; Arjen Amelink

doi:10.1117/1.3050424

1 November 2008 Empirical model description of photon path length for differential path length spectroscopy: combined effect of scattering and absorption

Stephen Chad Kanick, Henricus J. C. M. Sterenborg, Arjen Amelink

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Journal of Biomedical Optics, Vol. 13, Issue 6, 064042 (November 2008). https://doi.org/10.1117/1.3050424

Abstract

Differential path length spectroscopy (DPS) is a method of reflectance spectroscopy that utilizes a specialized fiber geometry to make the photon path length (τ) insensitive to variations in tissue optical properties over a wide range of absorption (μ_a) and total scattering (μ_s) coefficients, which are common within the ultraviolet/visible(UV/VIS) wavelength region. This study extends the description of τ to larger μ_a and smaller μ_s values, optical properties that are representative of the near-infrared region (NIR), a region where the DPS path length may be dependent on both coefficients. This study presents a novel empirical relationship between τ and the combined effect of both μ_a (range: 0.1–12 mm^-1) and μ_s (range: 1.5–42 mm^-1), anisotropy of 0.8, and is applicable to DPS probes containing a wide range of fiber diameters (range: 100–1000 μm). The results indicate that the simple empirical formula, including only one fitted parameter, is capable of accurately predicting over a wide range (r=0.985; range: 80–940 μm) and predictions are not biased versus μ_a or μ_s. This novel relationship is applicable to analysis of DPS measurements of tissue in both the UV/VIS and NIR wavelength regions and may provide information about the wavelength-specific tissue volume optically sampled during measurement.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Stephen Chad Kanick, Henricus J. C. M. Sterenborg, and Arjen Amelink "Empirical model description of photon path length for differential path length spectroscopy: combined effect of scattering and absorption," Journal of Biomedical Optics 13(6), 064042 (1 November 2008). https://doi.org/10.1117/1.3050424

Published: 1 November 2008

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