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1 November 2011 Estimating the density of fluorescent nanoparticles in the primo vessels in the fourth ventricle and the spinal cord of a rat
Jaekwan Lim, Jong Hyun Jung, Sungwoo Lee, Zhendong Su, Zhou Qiang, Kwangsup Soh, Jin-Myung Cha, Jin-Kyu Lee
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Journal of Biomedical Optics, Vol. 16, Issue 11, 116010 (November 2011). https://doi.org/10.1117/1.3647595
Abstract
The primo vascular system is a novel circulatory system forming a network throughout an animal's body. Primo vessels were recently observed in the fourth ventricle of the brain and in the spinal cord of a rat by using fluorescent nanoparticles. In order to quantify the nanoparticles in the primo vessels, we measured the florescence of the nanoparticles and calibrated the measurements by using a reference suspension. We removed the noise due to autofluorescence with the technique of multispectral imaging. The line densities of nanoparticles and the contrast values of their images were, respectively, 0.5 ± 0.5 ng/mm and 0.7 ± 0.5 for primo vessels in the fourth ventricle, and 1.3 ± 0.6 ng/mm and 1.4 ± 0.2 for primo vessels in the spinal cord. The data obtained from and the procedures used in this work could be useful in evaluating the feasibility of using nanoparticles as a contrast agent during MRI or CT imaging of primo vessels in the brain or the spinal cord.
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2011/16(11)/116010/7/$25.00
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Jaekwan Lim, Jong Hyun Jung, Sungwoo Lee, Zhendong Su, Zhou Qiang, Kwangsup Soh, Jin-Myung Cha, and Jin-Kyu Lee "Estimating the density of fluorescent nanoparticles in the primo vessels in the fourth ventricle and the spinal cord of a rat," Journal of Biomedical Optics 16(11), 116010 (1 November 2011). https://doi.org/10.1117/1.3647595
Published: 1 November 2011
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Cited by 22 scholarly publications.
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KEYWORDS
Nanoparticles
Spinal cord
Luminescence
Brain
Blood vessels
Neuroimaging
Calibration
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