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1 February 2011 In vivo photoacoustic imaging of osteosarcoma in a rat model
Jun Hu, Menglei Yu, Fei Ye, Da Xing
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Journal of Biomedical Optics, Vol. 16, Issue 2, 020503 (February 2011). https://doi.org/10.1117/1.3544502
Abstract
Osteosarcoma is one of the most common primary malignant tumors of the bone and the second leading cause of cancer-related deaths in the pediatric age group. Confirmed diagnosis and prompt treatment of osteosarcoma are critical for effective prognosis. In this study, we investigate the application of photoacoustic imaging (PAI) for the detection of osteosarcoma in an animal model. Cross-section images of a normal rat leg and a tumorous rat leg were successfully reconstructed in vivo. Morphological changes and the development of the implanted osteosarcoma were accurately mapped with time-dependent photoacoustic images. Furthermore, we evaluate the use of gold nanorods as contrast agents for imaging osteosarcoma with PAI. This is the first study that uses PAI to detect osteosarcoma invivo, and the results suggest that PAI has the potential clinical application for detecting osteosarcoma in the early stage.
©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Jun Hu, Menglei Yu, Fei Ye, and Da Xing "In vivo photoacoustic imaging of osteosarcoma in a rat model," Journal of Biomedical Optics 16(2), 020503 (1 February 2011). https://doi.org/10.1117/1.3544502
Published: 1 February 2011
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Cited by 15 scholarly publications.
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KEYWORDS
Tumors
In vivo imaging
Nanorods
Gold
Photoacoustic imaging
Animal model studies
Bone
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