Quantitative analysis on collagen morphology in aging skin based on multiphoton microscopy

Shulian Wu; Hui Li; Hongqin Yang; Xiaoman Zhang; Zhifang Li; Shufei Xu

doi:10.1117/1.3565439

1 April 2011 Quantitative analysis on collagen morphology in aging skin based on multiphoton microscopy

Shulian Wu, Hui Li, Hongqin Yang, Xiaoman Zhang, Zhifang Li, Shufei Xu

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Journal of Biomedical Optics, Vol. 16, Issue 4, 040502 (April 2011). https://doi.org/10.1117/1.3565439

Abstract

Multiphoton microscopy was employed for monitoring the structure changes of mouse dermis collagen in the intrinsic- or the extrinsic-age-related processes in vivo. The characteristics of textures in different aging skins were uncovered by fast Fourier transform in which the orientation index and bundle packing of collagen were quantitatively analyzed. Some significant differences in collagen-related changes are found in different aging skins, which can be good indicators for the statuses of aging skins. The results are valuable to the study of aging skin and also of interest to biomedical photonics.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Shulian Wu, Hui Li, Hongqin Yang, Xiaoman Zhang, Zhifang Li, and Shufei Xu "Quantitative analysis on collagen morphology in aging skin based on multiphoton microscopy," Journal of Biomedical Optics 16(4), 040502 (1 April 2011). https://doi.org/10.1117/1.3565439

Published: 1 April 2011

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