Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signals

Yunjie Tong; Lia Maria Hocke; Stephanie C. Licata; Blaise deB. Frederick

doi:10.1117/1.JBO.17.10.106004

1 October 2012 Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signals

Yunjie Tong, Lia Maria Hocke, Stephanie C. Licata, Blaise deB. Frederick

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Journal of Biomedical Optics, Vol. 17, Issue 10, 106004 (October 2012). https://doi.org/10.1117/1.JBO.17.10.106004

Abstract

Low-frequency oscillations (LFOs) in the range of 0.01-0.15 Hz are commonly observed in functional imaging studies, such as blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) and functional near-infrared spectroscopy (fNIRS). Some of these LFOs are nonneuronal and are closely related to autonomic physiological processes. In the current study, we conducted a concurrent resting-state fMRI and NIRS experiment with healthy volunteers. LFO data was collected simultaneously at peripheral sites (middle fingertip and big toes) by NIRS, and centrally in the brain by BOLD fMRI. The cross-correlations of the LFOs collected from the finger, toes, and brain were calculated. Our data show that the LFOs measured in the periphery (NIRS signals) and in the brain (BOLD fMRI) were strongly correlated with varying time delays. This demonstrates that some portion of the LFOs actually reflect systemic physiological circulatory effects. Furthermore, we demonstrated that NIRS is effective for measuring the peripheral LFOs, and that these LFOs and the temporal shifts between them are consistent in healthy participants and may serve as useful biomarkers for detecting and monitoring circulatory dysfunction.

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Yunjie Tong, Lia Maria Hocke, Stephanie C. Licata, and Blaise deB. Frederick "Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signals," Journal of Biomedical Optics 17(10), 106004 (1 October 2012). https://doi.org/10.1117/1.JBO.17.10.106004

Published: 1 October 2012

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