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7 October 2014 Inexpensive diffuse reflectance spectroscopy system for measuring changes in tissue optical properties
Diana L. Glennie, Joseph E. Hayward, Daniel E. McKee, Thomas J. Farrell
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Journal of Biomedical Optics, Vol. 19, Issue 10, 105005 (October 2014). https://doi.org/10.1117/1.JBO.19.10.105005
Abstract
The measurement of changes in blood volume in tissue is important for monitoring the effects of a wide range of therapeutic interventions, from radiation therapy to skin-flap transplants. Many systems available for purchase are either expensive or difficult to use, limiting their utility in the clinical setting. A low-cost system, capable of measuring changes in tissue blood volume via diffuse reflectance spectroscopy is presented. The system consists of an integrating sphere coupled via optical fibers to a broadband light source and a spectrometer. Validation data are presented to illustrate the accuracy and reproducibility of the system. The validity and utility of this in vivo system were demonstrated in a skin blanching/reddening experiment using epinephrine and lidocaine, and in a study measuring the severity of radiation-induced erythema during radiation therapy.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2014/$25.00 © 2014 SPIE
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Diana L. Glennie, Joseph E. Hayward, Daniel E. McKee, and Thomas J. Farrell "Inexpensive diffuse reflectance spectroscopy system for measuring changes in tissue optical properties," Journal of Biomedical Optics 19(10), 105005 (7 October 2014). https://doi.org/10.1117/1.JBO.19.10.105005
Published: 7 October 2014
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Cited by 12 scholarly publications and 1 patent.
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KEYWORDS
Reflectivity
Spectroscopy
Diffuse reflectance spectroscopy
Optical spheres
Skin
Integrating spheres
Tissue optics
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