Optimal estimation reconstruction of the optical properties of a two-layered tissue phantom from time-resolved single-distance measurements

Fabrizio Martelli; Samuele Del Bianco; Lorenzo Spinelli; Stefano Cavalieri; Paola Di Ninni; Tiziano Binzoni; Alexander Jelzow; Rainer Macdonald; Heidrun Wabnitz

doi:10.1117/1.JBO.20.11.115001

2 November 2015 Optimal estimation reconstruction of the optical properties of a two-layered tissue phantom from time-resolved single-distance measurements

Fabrizio Martelli, Samuele Del Bianco, Lorenzo Spinelli, Stefano Cavalieri, Paola Di Ninni, Tiziano Binzoni, Alexander Jelzow, Rainer Macdonald, Heidrun Wabnitz

Author Affiliations +

Journal of Biomedical Optics, Vol. 20, Issue 11, 115001 (November 2015). https://doi.org/10.1117/1.JBO.20.11.115001

Abstract

In this work, we have tested the optimal estimation (OE) algorithm for the reconstruction of the optical properties of a two-layered liquid tissue phantom from time-resolved single-distance measurements. The OE allows a priori information, in particular on the range of variation of fit parameters, to be included. The purpose of the present investigations was to compare the performance of OE with the Levenberg–Marquardt method for a geometry and real experimental conditions typically used to reconstruct the optical properties of biological tissues such as muscle and brain. The absorption coefficient of the layers was varied in a range of values typical for biological tissues. The reconstructions performed demonstrate the substantial improvements achievable with the OE provided a priori information is available. We note the extreme reliability, robustness, and accuracy of the retrieved absorption coefficient of the second layer obtained with the OE that was found for up to six fit parameters, with an error in the retrieved values of less than 10%. A priori information on fit parameters and fixed forward model parameters clearly improves robustness and accuracy of the inversion procedure.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Fabrizio Martelli, Samuele Del Bianco, Lorenzo Spinelli, Stefano Cavalieri, Paola Di Ninni, Tiziano Binzoni, Alexander Jelzow, Rainer Macdonald, and Heidrun Wabnitz "Optimal estimation reconstruction of the optical properties of a two-layered tissue phantom from time-resolved single-distance measurements," Journal of Biomedical Optics 20(11), 115001 (2 November 2015). https://doi.org/10.1117/1.JBO.20.11.115001

Published: 2 November 2015

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
12 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY