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17 November 2015 Oral cancer screening: serum Raman spectroscopic approach
Aditi Sahu, Suyash Dhoot, Amandeep Singh, Sharada Sawant, Nikhila Nandakumar, Sneha Talathi-Desai, Mandavi Garud, Sandeep Pagare, Sanjeeva Srivastava, Sudhir Nair, Pankaj Chaturvedi, C. Murali Krishna
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Journal of Biomedical Optics, Vol. 20, Issue 11, 115006 (November 2015). https://doi.org/10.1117/1.JBO.20.11.115006
Abstract
Serum Raman spectroscopy (RS) has previously shown potential in oral cancer diagnosis and recurrence prediction. To evaluate the potential of serum RS in oral cancer screening, premalignant and cancer-specific detection was explored in the present study using 328 subjects belonging to healthy controls, premalignant, disease controls, and oral cancer groups. Spectra were acquired using a Raman microprobe. Spectral findings suggest changes in amino acids, lipids, protein, DNA, and β-carotene across the groups. A patient-wise approach was employed for data analysis using principal component linear discriminant analysis. In the first step, the classification among premalignant, disease control (nonoral cancer), oral cancer, and normal samples was evaluated in binary classification models. Thereafter, two screening-friendly classification approaches were explored to further evaluate the clinical utility of serum RS: a single four-group model and normal versus abnormal followed by determining the type of abnormality model. Results demonstrate the feasibility of premalignant and specific cancer detection. The normal versus abnormal model yields better sensitivity and specificity rates of 64 and 80%; these rates are comparable to standard screening approaches. Prospectively, as the current screening procedure of visual inspection is useful mainly for high-risk populations, serum RS may serve as a useful adjunct for early and specific detection of oral precancers and cancer.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
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Aditi Sahu, Suyash Dhoot, Amandeep Singh, Sharada Sawant, Nikhila Nandakumar, Sneha Talathi-Desai, Mandavi Garud, Sandeep Pagare, Sanjeeva Srivastava, Sudhir Nair, Pankaj Chaturvedi, and C. Murali Krishna "Oral cancer screening: serum Raman spectroscopic approach," Journal of Biomedical Optics 20(11), 115006 (17 November 2015). https://doi.org/10.1117/1.JBO.20.11.115006
Published: 17 November 2015
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KEYWORDS
Cancer
Raman spectroscopy
Control systems
Remote sensing
Spectroscopy
Tumor growth modeling
Statistical analysis
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