CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 20 > Issue 3 > Article
Open Access
4 March 2015 Study of tissue oxygen supply rate in a macroscopic photodynamic therapy singlet oxygen model
Timothy C. Zhu, Baochang Liu, Rozhin Penjweini
Author Affiliations +
Journal of Biomedical Optics, Vol. 20, Issue 3, 038001 (March 2015). https://doi.org/10.1117/1.JBO.20.3.038001
Abstract
An appropriate expression for the oxygen supply rate (Γs) is required for the macroscopic modeling of the complex mechanisms of photodynamic therapy (PDT). It is unrealistic to model the actual heterogeneous tumor microvascular networks coupled with the PDT processes because of the large computational requirement. In this study, a theoretical microscopic model based on uniformly distributed Krogh cylinders is used to calculate Γs=g(1−[3O2]/[3O2]0) that can replace the complex modeling of blood vasculature while maintaining a reasonable resemblance to reality; g is the maximum oxygen supply rate and [3O2]/[3O2]0 is the volume-average tissue oxygen concentration normalized to its value prior to PDT. The model incorporates kinetic equations of oxygen diffusion and convection within capillaries and oxygen saturation from oxyhemoglobin. Oxygen supply to the tissue is via diffusion from the uniformly distributed blood vessels. Oxygen can also diffuse along the radius and the longitudinal axis of the cylinder within tissue. The relations of Γs to [3O2]/[3O2]0 are examined for a biologically reasonable range of the physiological parameters for the microvasculature and several light fluence rates (ϕ). The results show a linear relationship between Γs and [3O2]/[3O2]0, independent of ϕ and photochemical parameters; the obtained g ranges from 0.4 to 1390  μM/s.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
Citation Download Citation
Timothy C. Zhu, Baochang Liu, and Rozhin Penjweini "Study of tissue oxygen supply rate in a macroscopic photodynamic therapy singlet oxygen model," Journal of Biomedical Optics 20(3), 038001 (4 March 2015). https://doi.org/10.1117/1.JBO.20.3.038001
Published: 4 March 2015
JOURNAL ARTICLE
 13 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 45 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Oxygen
Photodynamic therapy
Capillaries
Tissues
Tissue optics
Blood
Diffusion
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top