Characterizing optical properties and spatial heterogeneity of human ovarian tissue using spatial frequency domain imaging

Sreyankar Nandy; Atahar Mostafa; Patrick D. Kumavor; Melinda Sanders; Molly Brewer; Quing Zhu

doi:10.1117/1.JBO.21.10.101402

28 January 2016 Characterizing optical properties and spatial heterogeneity of human ovarian tissue using spatial frequency domain imaging

Sreyankar Nandy, Atahar Mostafa, Patrick D. Kumavor, Melinda Sanders, Molly Brewer, Quing Zhu

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Journal of Biomedical Optics, Vol. 21, Issue 10, 101402 (January 2016). https://doi.org/10.1117/1.JBO.21.10.101402

Abstract

A spatial frequency domain imaging (SFDI) system was developed for characterizing ex vivo human ovarian tissue using wide-field absorption and scattering properties and their spatial heterogeneities. Based on the observed differences between absorption and scattering images of different ovarian tissue groups, six parameters were quantitatively extracted. These are the mean absorption and scattering, spatial heterogeneities of both absorption and scattering maps measured by a standard deviation, and a fitting error of a Gaussian model fitted to normalized mean Radon transform of the absorption and scattering maps. A logistic regression model was used for classification of malignant and normal ovarian tissues. A sensitivity of 95%, specificity of 100%, and area under the curve of 0.98 were obtained using six parameters extracted from the SFDI images. The preliminary results demonstrate the diagnostic potential of the SFDI method for quantitative characterization of wide-field optical properties and the spatial distribution heterogeneity of human ovarian tissue. SFDI could be an extremely robust and valuable tool for evaluation of the ovary and detection of neoplastic changes of ovarian cancer.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Sreyankar Nandy, Atahar Mostafa, Patrick D. Kumavor, Melinda Sanders, Molly Brewer, and Quing Zhu "Characterizing optical properties and spatial heterogeneity of human ovarian tissue using spatial frequency domain imaging," Journal of Biomedical Optics 21(10), 101402 (28 January 2016). https://doi.org/10.1117/1.JBO.21.10.101402

Published: 28 January 2016

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