Application of functional data analysis in classification and clustering of functional near-infrared spectroscopy signal in response to noxious stimuli

Ahmad Pourshoghi; Issa Zakeri; Kambiz Pourrezaei

doi:10.1117/1.JBO.21.10.101411

6 May 2016 Application of functional data analysis in classification and clustering of functional near-infrared spectroscopy signal in response to noxious stimuli

Ahmad Pourshoghi, Issa Zakeri, Kambiz Pourrezaei

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Journal of Biomedical Optics, Vol. 21, Issue 10, 101411 (May 2016). https://doi.org/10.1117/1.JBO.21.10.101411

Abstract

We introduce the application of functional data analysis (fDA) on functional near-infrared spectroscopy (fNIRS) signals for the development of an accurate and clinically practical assessment method of pain perception. We used the cold pressor test to induce different levels of pain in healthy subjects while the fNIRS signal was recorded from the frontal regions of the brain. We applied fDA on the collected fNIRS data to convert discrete samples into continuous curves. This method enabled us to represent the curves as a linear combination of basis functions. We utilized bases coefficients as features that represent the shape of the signals (as opposed to extracting defined features from signal) and used them to train a support vector machine to classify the signals based on the level of induced pain. We achieved 94% of accuracy to classify low-pain and high-pain signals. Moreover applying hierarchical clustering on the coefficients, we found three clusters in the data which represented low-pain (one cluster) and high-pain groups (two clusters) with an accuracy of 91.2%. The center of these clusters can represent the prototype fNIRS response of that pain level.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Ahmad Pourshoghi, Issa Zakeri, and Kambiz Pourrezaei "Application of functional data analysis in classification and clustering of functional near-infrared spectroscopy signal in response to noxious stimuli," Journal of Biomedical Optics 21(10), 101411 (6 May 2016). https://doi.org/10.1117/1.JBO.21.10.101411

Published: 6 May 2016

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