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13 July 2017 Analysis of skin blood microflow oscillations in patients with rheumatic diseases
Irina Mizeva, Irina Makovik, Andrey Dunaev, Alexander Krupatkin M.D., Igor Meglinski
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Funded by: Russian Foundation for Basic Research (RFBR), Russian Science Foundation
Journal of Biomedical Optics, Vol. 22, Issue 7, 070501 (July 2017). https://doi.org/10.1117/1.JBO.22.7.070501
Abstract
Laser Doppler flowmetry (LDF) has been applied for the assessment of variation in blood microflows in patients with rheumatic diseases and healthy volunteers. Oscillations of peripheral blood microcirculation observed by LDF have been analyzed utilizing a wavelet transform. A higher amplitude of blood microflow oscillations has been observed in a high frequency band (over 0.1 Hz) in patients with rheumatic diseases. Oscillations in the high frequency band decreased in healthy volunteers in response to the cold pressor test, whereas lower frequency pulsations prevailed in patients with rheumatic diseases. A higher perfusion rate at normal conditions was observed in patients, and a weaker response to cold stimulation was observed in healthy volunteers. Analysis of blood microflow oscillations has a high potential for evaluation of mechanisms of blood flow regulation and diagnosis of vascular abnormalities associated with rheumatic diseases.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Irina Mizeva, Irina Makovik, Andrey Dunaev, Alexander Krupatkin M.D., and Igor Meglinski "Analysis of skin blood microflow oscillations in patients with rheumatic diseases," Journal of Biomedical Optics 22(7), 070501 (13 July 2017). https://doi.org/10.1117/1.JBO.22.7.070501
Received: 25 May 2017; Accepted: 21 June 2017; Published: 13 July 2017
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KEYWORDS
Blood
Skin
Blood circulation
Wavelets
Doppler tomography
Optical coherence tomography
Wavelet transforms
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