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7 August 2018 Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy
Joseph Chue-Sang, Nola Holness, Mariacarla Gonzalez, Joan Greaves, Ilyas Saytashev, Susan Stoff, Amir Gandjbakhche, Viktor V. Chernomordik, Gene Burkett, Jessica C. Ramella-Roman
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Journal of Biomedical Optics, Vol. 23, Issue 12, 121605 (August 2018). https://doi.org/10.1117/1.JBO.23.12.121605
Abstract
Annually, about 15 million preterm infants are born in the world. Of these, due to complications resulting from their premature birth, about 1 million would die before the age of five. Since the high incidence of preterm birth (PTB) is partially due to the lack of effective diagnostic modalities, methodologies are needed to determine risk of PTB. We propose a noninvasive tool based on polarized light imaging aimed at measuring the organization of collagen in the cervix. Cervical collagen has been shown to remodel with the approach of parturition. We used a full-field Mueller matrix polarimetric colposcope to assess and compare cervical collagen content and structure in nonpregnant and pregnant women in vivo. Local collagen directional azimuth was used and a total of eight cervices were imaged.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Joseph Chue-Sang, Nola Holness, Mariacarla Gonzalez, Joan Greaves, Ilyas Saytashev, Susan Stoff, Amir Gandjbakhche, Viktor V. Chernomordik, Gene Burkett, and Jessica C. Ramella-Roman "Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy," Journal of Biomedical Optics 23(12), 121605 (7 August 2018). https://doi.org/10.1117/1.JBO.23.12.121605
Received: 21 March 2018; Accepted: 23 July 2018; Published: 7 August 2018
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KEYWORDS
Cervix
Collagen
Anisotropy
In vivo imaging
Polarimetry
Polarization
Wave plates
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